Najib El-Sayed
Professor
3246 Iribe Center
(301) 405-2999
Research Group(s):
Education:
Ph.D., Yale University (Molecular Parasitology)
Biography:
Najib El-Sayed is a professor of cell biology and molecular genetics with an appointment in the University of Maryland Institute for Advanced Computer Studies.
His research uses genomic and bioinformatics tools to study parasitism and host-pathogen interactions, aiming to understand infection and survival mechanisms. Ultimately, he seeks to enhance the diagnosis, prevention and treatment of diseases caused by parasites and bacteria in humans, animals and plants.
Go here to view El-Sayed's academic publications on Google Scholar.
Publications
2008
2008. Role of transposable elements in trypanosomatids. Microbes and Infection. 10(6):575-581.
2008. Sequence diversity and evolution of multigene families in Trypanosoma cruzi. Molecular and Biochemical Parasitology. 157(1):65-72.
2007
2007. Schistosoma mansoni genome: Closing in on a final gene set. Experimental Parasitology. 117(3):225-228.
2007. Cofactor-independent phosphoglycerate mutase is an essential gene in procyclic form Trypanosoma brucei. Parasitology research. 100(4):887-892.
2007. Microarray analysis of gene expression induced by sexual contact in Schistosoma mansoni. BMC Genomics. 8(1):181-181.
2007. New Trypanosoma cruzi Repeated Element That Shows Site Specificity for Insertion. Eukaryotic Cell. 6(7):1228-1238.
2006
2006. The Trypanosoma cruzi L1Tc and NARTc non-LTR retrotransposons show relative site specificity for insertion. Molecular biology and evolution. 23(2):411-411.
2006. Evolution of non-LTR retrotransposons in the trypanosomatid genomes: Leishmania major has lost the active elements. Molecular and Biochemical Parasitology. 145(2):158-170.
2006. Schistosoma mansoni (Platyhelminthes, Trematoda) nuclear receptors: Sixteen new members and a novel subfamily. Gene. 366(2):303-315.
2005
2005. Promoter architecture and response to a positive regulator of archaeal transcription. Molecular Microbiology. 56(3):625-637.
2005. The Genome Sequence of Trypanosoma Cruzi, Etiologic Agent of Chagas Disease. ScienceScience. 309(5733):409-415.
2005. The Genome Sequence of Trypanosoma cruzi, Etiologic Agent of Chagas Disease. Science. 309(5733):409-415.
2005. Transcriptional profiling of the hyperthermophilic methanarchaeon Methanococcus jannaschii in response to lethal heat and non‐lethal cold shock. Environmental Microbiology. 7(6):789-797.
2005. The genetic map and comparative analysis with the physical map of Trypanosoma brucei. Nucleic acids research. 33(21):6688-6688.
2005. Comparative Genomics of Trypanosomatid Parasitic Protozoa. Science. 309(5733):404-409.
2004
2004. Sequencing Strategies for Parasite Genomes. METHODS IN MOLECULAR BIOLOGY-CLIFTON THEN TOTOWA-. 270:1-16.
2004. The ingi and RIME non-LTR retrotransposons are not randomly distributed in the genome of Trypanosoma brucei. Molecular biology and evolution. 21(3):520-520.
2004. Schistosoma mansoni genome project: an update. Parasitology International. 53(2):183-192.
2004. Advances in schistosome genomics. Trends in Parasitology. 20(4):154-157.
2003
2003. The sequence and analysis of Trypanosoma brucei chromosome II. Nucleic acids research. 31(16):4856-4856.
2002
2002. Trypanosoma cruzi: RNA structure and post-transcriptional control of tubulin gene expression. Experimental Parasitology. 102(3-4):123-133.
2002. Identification of non-autonomous non-LTR retrotransposons in the genome of Trypanosoma cruzi. Molecular and Biochemical Parasitology. 124(1-2):73-78.
2002. Analysis of stage-specific gene expression in the bloodstream and the procyclic form of Trypanosoma brucei using a genomic DNA-microarray. Molecular and Biochemical Parasitology. 123(2):115-123.
2001
2001. Analysis of a donor gene region for a variant surface glycoprotein and its expression site in African trypanosomes. Nucleic acids research. 29(10):2012-2012.
2000
2000. The African trypanosome genome. International Journal for Parasitology. 30(4):329-345.
1999
1999. More surprises from Kinetoplastida. Proceedings of the National Academy of Sciences of the United States of America. 96(6):2579-2579.
1998
1998. Multiple mechanisms of immune evasion by African trypanosomes. Molecular and Biochemical Parasitology. 91(1):51-66.
1997
1997. A survey of the Trypanosoma brucei rhodesiense genome using shotgun sequencing. Molecular and Biochemical Parasitology. 84(2):167-178.
1997. African trypanosomes have differentially expressed genes encoding homologues of the Leishmania GP63 surface protease. Journal of Biological Chemistry. 272(42):26742-26742.
1996
1996. Differential expression of the expression site-associated gene I family in African trypanosomes. Journal of Biological Chemistry. 271(16):9771-9771.
1995
1995. cDNA expressed sequence tags of Trypanosoma brucei rhodesiense provide new insights into the biology of the parasite. Molecular and Biochemical Parasitology. 73(1-2):75-90.
1995. Crystallization and preliminary X-ray investigation of the recombinant Trypanosoma brucei rhodesiense calmodulin. Proteins: Structure, Function, and Bioinformatics. 21(4):354-357.